Article
Carboxyl-terminal truncation of apolipoprotein B results in gradual loss of the ability to form buoyant lipoproteins in cultured human and rat liver cell lines.
Biochemistry - 4 Jun 1991
Graham D L, Knott T J, Jones T C, Pease R J, Pullinger C R, Scott J
Abstract excerpt
Apolipoprotein B has an obligatory role in the production of chylomicrons, VLDL, and LDL. Familial hypobetalipoproteinemia is a codominant disorder characterized by reduced levels of apo B containing lipoproteins in plasma. We have previously described mutations of the apo B gene in persons with hypobetalipoproteinemia that predict truncated forms of apo B designated apo B29 (1305 amino acid residues) and apo B39...
Topics
- Animals
- Apolipoproteins B
- DNA
- Gene Expression
- Humans
- Lipoproteins, LDL
- Lipoproteins, VLDL
- Liver
- Mutation
- Precipitin Tests
- Rats