Article
Inactivating mutations of proapoptotic Bad gene in human colon cancers.
Carcinogenesis - 1 Aug 2004
Lee Jong Woo, Soung Young Hwa, Kim Su Young, Nam Suk Woo, Kim Chang Jae, Cho Yong Gu, Lee Jong Heun, Kim Hong Sug, Park Won Sang, Kim Sang Ho, Lee Jung Young, Yoo Nam Jin, Lee Sug Hyung
Abstract excerpt
Evidence exists that deregulation of apoptosis is involved in the mechanisms of cancer development, and the somatic mutations of apoptosis-related genes have been reported in human cancers. Bcl-XL/Bcl-2-associated death promoter (Bad), a proapoptotic member of Bcl-2 family, plays an important rol...
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