The porA gene in serogroup A meningococci: evolutionary stability and mechanism of genetic variation.

doi:10.1111/j.1365-2958.1994.tb01014.x

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Article

The porA gene in serogroup A meningococci: evolutionary stability and mechanism of genetic variation.

Molecular microbiology - 1 Apr 1994

Suker J, Feavers I M, Achtman M, Morelli G, Wang J F, Maiden M C

Abstract excerpt

Molecular analyses were applied to the genes encoding variants of the serosubtyping antigen, the class 1 outer membrane protein (PorA), from 55 serogroup A Neisseria meningitidis strains. These genes were evolutionarily stable and exhibited a limited range of genetic variation, primarily generated by recombination. Translation of the gene sequences revealed a total of 19 distinct amino acid sequences in the...

Topics

Alleles
Amino Acid Sequence
Animals
Antibodies, Bacterial
Antibodies, Monoclonal
Antigenic Variation
Bacterial Outer Membrane Proteins
Base Sequence
China
England
Genes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Meningitis, Meningococcal

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Neisseria meningitidis

Peptide Fragments

Source

Open in PubMed

Identifiers

PMID: 8057850
DOI: 10.1111/j.1365-2958.1994.tb01014.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8057850-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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