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Article

Distribution of surface protein variants among hyperinvasive meningococci: implications for vaccine design.

Infection and immunity - 1 Oct 2004

Urwin Rachel, Russell Joanne E, Thompson Emily A L, Holmes Edward C, Feavers Ian M, Maiden Martin C J

Abstract excerpt

The bacterium Neisseria meningitidis is a major cause of meningitis and septicemia worldwide. Outer membrane proteins (OMPs) are candidates in the search for comprehensive meningococcal vaccines; however, the formulation of OMP vaccines is complicated by antigenic diversity, which is generated by high levels of genetic reassortment and strong positive selection in the meningococcal antigen genes. The genetic and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15385499
DOI: 10.1128/IAI.72.10.5955-5962.2004
PMCID: PMC517544

Genes

OMP

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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