Article
The immunocytochemical detection of p53 protein in cytological specimens: technical considerations.
Cytopathology : official journal of the British Society for Clinical Cytology - 1 Apr 1994
Dowell S P, Lane D P, Hall P A
Abstract excerpt
The p53 gene encodes a 393 amino acid nuclear phosphoprotein that appears to act as a cell cycle checkpoint, possibly by transactivating other target genes. Abnormalities of the p53 gene are common in a wide range of human tumours and are associated in many cases with immunologically detectable p...
Topics
- Cell Line
- Cytological Techniques
- Humans
- Immunoenzyme Techniques
- Mutation
- Tumor Suppressor Protein p53