Article
Epidemic neuropathy in Cuba not associated with mitochondrial DNA mutations found in Leber's hereditary optic neuropathy patients. Cuba Neuropathy Field Investigation Team.
American journal of ophthalmology - 15 Aug 1994
Newman N J, Torroni A, Brown M D, Lott M T, Fernandez M M, Wallace D C
Abstract excerpt
An epidemic neuropathy in Cuba has caused bilateral optic neuropathies in more than 26,000 people during the past three years. Various pathogenetic factors have been proposed, including toxins, nutritional deficiencies, and an underlying genetic predisposition involving mitochondrial DNA. As part...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Cuba
- DNA, Mitochondrial
- Disease Outbreaks
- Electrophoresis, Agar Gel
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Optic Atrophies, Hereditary
- Optic Nerve Diseases
- Pedigree
- Polymerase Chain Reaction