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Article

The epidemiology of Leber hereditary optic neuropathy in the North East of England.

American journal of human genetics - 1 Feb 2003

Yu-Wai-Man P, Griffiths P G, Brown D T, Howell N, Turnbull D M, Chinnery P F

Abstract excerpt

We performed the first population-based clinical and molecular genetic study of Leber hereditary optic neuropathy (LHON) in a population of 2,173,800 individuals in the North East of England. We identified 16 genealogically unrelated families who harbor one of the three primary mitochondrial DNA (mtDNA) mutations that cause LHON. Two of these families were found to be linked genetically to a common maternal...

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Identifiers

PMID: 12518276
DOI: 10.1086/346066
PMCID: PMC379226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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