Article
Mitochondrial DNA mutations in an outbreak of optic neuropathy in Cuba.
Neurology - 1 May 1994
Hirano M, Cleary J M, Stewart A M, Lincoff N S, Odel J G, Santiesteban R, Santiago Luis R
Abstract excerpt
Since October 1991, nearly 51,000 Cubans have been afflicted in an outbreak of optic and peripheral neuropathies. To begin an investigation of the possible role of mitochondrial DNA (mtDNA) mutations in the outbreak, we studied mtDNA from 14 affected and two unaffected Cubans for the 12 mutations associated with Leber's hereditary optic neuropathy. Eleven probands (12 patients) had optic neuropathy and two had...
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