Mitochondrial DNA mutations in an outbreak of optic neuropathy in Cuba.

doi:10.1212/wnl.44.5.843

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Article

Mitochondrial DNA mutations in an outbreak of optic neuropathy in Cuba.

Neurology - 1 May 1994

Hirano M, Cleary J M, Stewart A M, Lincoff N S, Odel J G, Santiesteban R, Santiago Luis R

Abstract excerpt

Since October 1991, nearly 51,000 Cubans have been afflicted in an outbreak of optic and peripheral neuropathies. To begin an investigation of the possible role of mitochondrial DNA (mtDNA) mutations in the outbreak, we studied mtDNA from 14 affected and two unaffected Cubans for the 12 mutations...

Topics

Base Sequence
Cuba
DNA, Mitochondrial
Disease Outbreaks
Humans
Molecular Sequence Data
Mutation
Optic Atrophies, Hereditary

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