Cuban epidemic optic neuropathy. Mitochondrial DNA analysis.

Article

Cuban epidemic optic neuropathy. Mitochondrial DNA analysis.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society - 1 Sept 1994

Johns D R, Sadun A A

Abstract excerpt

OBJECTIVE: To search for mitochondrial DNA (mtDNA) mutations previously associated with Leber's hereditary optic neuropathy (LHON) in patients with an optic neuropathy that appeared in epidemic form in Cuba. METHODS: Twelve Cuban patients underwent a comprehensive neuro-ophthalmologic examination...

Topics

Cuba
DNA Mutational Analysis
DNA, Mitochondrial
Disease Outbreaks
Female
Humans
Male
Mutation
Optic Atrophies, Hereditary
Optic Nerve Diseases
Polymerase Chain Reaction
Risk Factors

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