Article
Vitamin B12 in Leber hereditary optic neuropathy mutation carriers: a prospective cohort study.
Orphanet journal of rare diseases - 9 Aug 2022
Zibold Julia, von Livonius Bettina, Kolarova Hana, Rudolph Günter, Priglinger Claudia S, Klopstock Thomas, Catarino Claudia B
Abstract excerpt
BACKGROUND: Leber hereditary optic neuropathy (LHON) is the most common mitochondrial disorder, frequently resulting in acute or subacute severe bilateral central vision loss. Vitamin B12 deficiency is also a known cause of optic neuropathy through mitochondrial dysfunction. Here we evaluated the prevalence and clinical significance of vitamin B12 deficiency in a large cohort of LHON patients and asymptomatic...
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