Spectrum of the mitochondrial DNA mutations of Leber's hereditary optic neuropathy in Koreans.

doi:10.1007/s00415-003-0985-4

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Article

Spectrum of the mitochondrial DNA mutations of Leber's hereditary optic neuropathy in Koreans.

Journal of neurology - 1 Mar 2003

Kim Ji Yeon, Hwang Jeong-Min, Chang Bong-Leen, Park Sung Sup

Abstract excerpt

We investigated 14 primary mitochondrial DNA (mtDNA) mutations at nucleotide positions (nps) 3460A, 4160C, 5244A, 9101C, 9804A, 10663C, 11778A, 13730A, 14459A, 14482G, 14484C, 14495G, 14498T, and 14568T, and one common secondary mutation at np 15257A, in 82 Korean patients with suspected Leber's hereditary optic neuropathy (LHON). Only three kinds of LHON mutations were identified in 60 (73 %) of the 82 probands,...

Topics

DNA Mutational Analysis
DNA, Mitochondrial
Humans
Korea
Mutation
Optic Atrophy, Hereditary, Leber
Polymerase Chain Reaction
Prevalence

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Open in PubMed

Identifiers

PMID: 12638016
DOI: 10.1007/s00415-003-0985-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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