Article
Mitochondrial DNA mutations in Cuban optic and peripheral neuropathy.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society - 1 Sept 1994
Johns D R, Neufeld M J, Hedges T R
Abstract excerpt
OBJECTIVE: To investigate the potential role of mitochondrial DNA (mtDNA) mutations in the recent outbreak in Cuba of optic neuropathy and peripheral neuropathy (COPN). DESIGN AND METHODS: Historical features were reviewed and neuro-ophthalmologic examinations were performed on a sample of COPN patients (n = 9) and Cuban patients with other forms of optic neuropathy (n = 2). Molecular genetic methods were then...
Topics
- Adult
- Cuba
- DNA, Mitochondrial
- Disease Outbreaks
- Electron Transport Complex IV
- Female
- Haplotypes
- Humans
- Male
- Middle Aged
- Mutation
- Optic Atrophies, Hereditary