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Article

Identification of C3b-binding regions on herpes simplex virus type 2 glycoprotein C.

Journal of virology - 1 May 1990

Seidel-Dugan C, Ponce de Leon M, Friedman H M, Eisenberg R J, Cohen G H

Abstract excerpt

Glycoprotein C from herpes simplex viruses types 1 and 2 (gC-1 and gC-2) acts as a receptor for the C3b fragment of the third component of complement. Our goal is to identify domains on gC involved in C3b receptor activity. Here, we used in-frame linker-insertion mutagenesis of the cloned gene for gC-2 to identify regions of the protein involved in C3b binding. We constructed 41 mutants of gC-2, each having a...

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Identifiers

PMID: 2157859
DOI: 10.1128/JVI.64.5.1897-1906.1990
PMCID: PMC249343

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