Article
Protein-DNA interactions within DNase I-hypersensitive sites located downstream of the HIV-1 promoter.
The Journal of biological chemistry - 5 Aug 1994
el Kharroubi A, Verdin E
Abstract excerpt
We have examined by in vitro footprinting a region located downstream of the human immunodeficiency virus, type 1 (HIV-1) promoter found to be hypersensitive to DNase I digestion in vivo. Recognition sites for several constitutive or inducible DNA binding factors were identified. Three AP-1 binding sites and an AP-3-like motif were situated within the R-U5 region of the long terminal repeat. A novel purine-rich...
Topics
- Base Sequence
- Cells, Cultured
- DNA, Viral
- DNA-Binding Proteins
- Deoxyribonuclease I
- HIV-1
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic