Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1.

doi:10.1128/JVI.64.10.5226-5229.1990

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Article

Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1.

Journal of virology - 1 Oct 1990

Lu Y C, Touzjian N, Stenzel M, Dorfman T, Sodroski J G, Haseltine W A

Abstract excerpt

The negative regulatory element of human immunodeficiency virus type 1 is a 260-nucleotide-long sequence that decreases the rate of RNA transcription initiation specified by the long terminal repeat. This region has the potential to bind several cellular transcription factors. Here it is shown that sequences which recognize the NFAT-1 and USF cellular transcription factors contribute to this negative regulatory...

Topics

Base Sequence
Cell Line
Cell Nucleus
Chromosome Deletion
Genes, Viral
HIV-1
HeLa Cells
Humans
Kinetics
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Promoter Regions, Genetic

Proviruses

Repetitive Sequences, Nucleic Acid

Transcription, Genetic

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 2398545
DOI: 10.1128/JVI.64.10.5226-5229.1990
PMCID: PMC248024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2398545-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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