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Article

Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor.

Cell - 29 Jul 1994

Penton A, Chen Y, Staehling-Hampton K, Wrana J L, Attisano L, Szidonya J, Cassill J A, Massagué J, Hoffmann F M

Abstract excerpt

Drosophila sequences at chromosomal positions 25D (Brk25D) and 43E (Brk43E) are similar to the TGF beta type I receptor serine/threonine kinases and are expressed broadly during embryogenesis. Brk25D binds dpp protein and bone morphogenetic protein 2 with high affinity. Mutations affecting Brk25D map to the gene thick veins and block the expression of two decapentaplegic-responsive (dpp-responsive) genes, dpp and...

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Identifiers

PMID: 8044838
DOI: 10.1016/0092-8674(94)90294-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor.PMID 8044838Read ↗

Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic.Semantic proximity Read ↗

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Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2.Semantic proximity Read ↗

A screen for modifiers of decapentaplegic mutant phenotypes identifies lilliputian, the only member of the Fragile-X/Burkitt's Lymphoma family of transcription factors in Drosophila melanogaster.Semantic proximity Read ↗

An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo.Semantic proximity Read ↗

A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A.Semantic proximity Read ↗

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.Semantic proximity Read ↗

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