Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor.

doi:10.1016/0092-8674(94)90294-1

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Article

Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor.

Cell - 29 Jul 1994

Penton A, Chen Y, Staehling-Hampton K, Wrana J L, Attisano L, Szidonya J, Cassill J A, Massagué J, Hoffmann F M

Abstract excerpt

Drosophila sequences at chromosomal positions 25D (Brk25D) and 43E (Brk43E) are similar to the TGF beta type I receptor serine/threonine kinases and are expressed broadly during embryogenesis. Brk25D binds dpp protein and bone morphogenetic protein 2 with high affinity. Mutations affecting Brk25D...

Topics

Amino Acid Sequence
Animals
Base Sequence
Bone Morphogenetic Proteins
Cloning, Molecular
DNA, Complementary
Drosophila
Drosophila Proteins
Gene Expression Regulation
Genes, Insect
Insect Hormones
Molecular Sequence Data
Mutation
Protein Serine-Threonine Kinases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteins

RNA, Messenger

Receptors, Cell Surface

Receptors, Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 8044838
DOI: 10.1016/0092-8674(94)90294-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8044838-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.