Article
Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells.
The New England journal of medicine - 5 Oct 1995
Hummel M, Ziemann K, Lammert H, Pileri S, Sabattini E, Stein H
Abstract excerpt
BACKGROUND: There is strong evidence that Reed-Sternberg cells have a lymphoid phenotype, but clonally rearranged genes for B-cell and T-cell antigen receptors have not been demonstrable in tumor tissue from most patients with Hodgkin's disease. To elucidate this issue, we assayed single Reed-Sternberg cells from 12 patients with classic Hodgkin's disease of a B-cell immunophenotype to detect rearranged...
Topics
- Adolescent
- Adult
- Antigens, CD
- Antigens, CD20
- Antigens, Differentiation, B-Lymphocyte
- B-Lymphocytes
- Child
- Clone Cells
- Female
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin