Article
Mutations of the immunoglobulin heavy chain variable region gene in CD99-deficient BJAB cell line.
Molecules and cells - 30 Apr 2002
Suh Young Ho, Kim Min Kyung, Shin Young Kee, Kim Seok Hyung, Oh Kwon Ik, Gil Minchan, Kim Min Kyung, Choi Yoon-La, Jung Kyeong Cheon, Lee Kyung-Mi, Lee Im-Soon, Park Seong Hoe
Abstract excerpt
Hodgkin's disease (HD) is a lymphoid neoplasm characterized by a low frequency of malignant giant tumor cells, known as Hodgkin's and Reed-Sternberg (HRS) cells. Sequence analysis of the immunoglobulin heavy chain hypervariable region (IgH V) genes of HRS cells revealed multiple nucleotide substitutions, indicating somatic mutations, and suggested that HRS cells originate from germinal center B cells or their...
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