Article
Molecular analysis of Hodgkin's disease with abundant Reed-Sternberg cells.
Hematologic pathology - 1 Jan 1990
Hu E H, Ellison D, Zovich D, Nichols P, Pattengale P
Abstract excerpt
The pathogenesis of Hodgkin's disease (HD) has been elusive largely because of the paucity of the Reed-Sternberg cells in comparison to large numbers of normal inflammatory cells in biopsy specimens. This report attempts to characterize Hodgkin's disease by studying subtypes with a high proportion of Reed-Sternberg cells and their variants. We found in 4 out of 6 cases, clonal heavy and light chain immunoglobulin...
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