Article
Why are estrogen-receptor-negative breast cancers more aggressive than the estrogen-receptor-positive breast cancers?
Invasion & metastasis - 1 Jan 2000
Sheikh M S, Garcia M, Pujol P, Fontana J A, Rochefort H
Abstract excerpt
It is well established that some of the hormone-resistant breast cancers lack functional estrogen receptor (ER) and exhibit a more aggressive metastatic phenotype. The estrogen activation of ER in ER-positive breast cancers enhances their aggressiveness, while the activation of exogenously introduced ERs into aggressive ER-negative cells diminishes their aggressiveness. The basis of the protective effect of the...
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