Article
Rapamycin extends maximal lifespan in cancer-prone mice.
The American journal of pathology - 1 May 2010
Anisimov Vladimir N, Zabezhinski Mark A, Popovich Irina G, Piskunova Tatiana S, Semenchenko Anna V, Tyndyk Margarita L, Yurova Maria N, Antoch Marina P, Blagosklonny Mikhail V
Abstract excerpt
Aging is associated with obesity and cancer. Calorie restriction both slows down aging and delays cancer. Evidence has emerged that the nutrient-sensing mammalian target of rapamycin (mTOR) pathway is involved in cellular and organismal aging. Here we show that the mTOR inhibitor rapamycin prevents age-related weight gain, decreases rate of aging, increases lifespan, and suppresses carcinogenesis in transgenic...
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