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Article

Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice.

Gastroenterology - 1 Mar 2012

Li Qiang, Jia Zhiliang, Wang Li, Kong Xiangyu, Li Qi, Guo Kun, Tan Dongfeng, Le Xiangdong, Wei Daoyan, Huang Suyun, Mishra Lopa, Xie Keping

Abstract excerpt

BACKGROUND & AIMS: Krüppel-like factor 4 (Klf4) is a putative gastric tumor suppressor gene. Rare, villin-positive progenitor cells in the gastric antrum have multilineage potential. We investigated the function of Klf4 in these cells and in gastric carcinogenesis. METHODS: We created mice with disruption of Klf4 in villin-positive antral mucosa cells (Villin-Cre(+);Klf4(fl/fl) mice). Villin-Cre(+);Klf4(fl/fl)...

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Identifiers

PMID: 22155367
DOI: 10.1053/j.gastro.2011.11.034
PMCID: PMC3477581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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