Article
Random mutagenesis of Schizosaccharomyces pombe SRP RNA: lethal and conditional lesions cluster in presumptive protein binding sites.
Nucleic acids research - 11 Apr 1992
Liao X, Selinger D, Althoff S, Chiang A, Hamilton D, Ma M, Wise J A
Abstract excerpt
Signal recognition particle (SRP), a ribonucleoprotein composed of six polypeptides and one RNA subunit, serves as an adaptor between the cytoplasmic protein synthetic machinery and the translocation apparatus of the endoplasmic reticulum. To begin constructing a functional map of the 7SL RNA com...
Topics
- Alleles
- Base Sequence
- Binding Sites
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Nucleic Acid Conformation
- Osmotic Pressure
- RNA, Fungal
- RNA, Nuclear
- Ribonucleoproteins
- Schizosaccharomyces
- Signal Recognition Particle
- Temperature