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Article

Structural insights into bacterial resistance to cerulenin

19 Mar 2014

Abstract excerpt

UNLABELLED: Cerulenin is a fungal toxin that inhibits both eukaryotic and prokaryotic ketoacyl-acyl carrier protein synthases or condensing enzymes. It has been used experimentally to treat cancer and obesity, and is a potent inhibitor of bacterial growth. Understanding the molecular mechanisms of resistance to cerulenin and similar compounds is thus highly relevant for human health. We have previously described...

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PMID: 24641521
DOI: 10.1111/febs.12785

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