Article
Influence of genetic variation in alcohol and aldehyde dehydrogenase on serotonin metabolism.
Life sciences - 1 Jan 1994
Helander A, Walzer C, Beck O, Balant L, Borg S, von Wartburg J P
Abstract excerpt
The influence of genetic variation in alcohol dehydrogenase (ADH; EC 1.1.1.1) and aldehyde dehydrogenase (ALDH; EC 1.2.1.3) on the metabolic pattern of serotonin (5-hydroxytryptamine, 5-HT) in humans was examined from the relative urinary concentrations of the end products 5-hydroxyindole-3-acetic acid (5-HIAA) and 5-hydroxytryptophol (5-HTOL). Healthy Caucasian (Swedish) and Oriental (Chinese) subjects were...
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