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Article

Microsatellite instability and defects in mismatch repair proteins: a new aetiology for Sertoli cell-only syndrome

1 Feb 2003

Abstract excerpt

Microsatellite instability is characteristic of certain types of cancer, and is present in rodents lacking specific DNA mismatch repair proteins. These azoospermic mice exhibit spermatogenic defects similar to some human testicular failure patients. Therefore, we hypothesized that microsatellite instability due to deficiencies in mismatch repair genes might be an unrecognized aetiology of human testicular...

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PMID: 12569174
DOI: 10.1093/molehr/gag013

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