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Article

Neomycin inhibits glycoprotein C (gC)-dependent binding of herpes simplex virus type 1 to cells and also inhibits postbinding events in entry.

Virology - 15 Aug 1994

Herold B C, Spear P G

Abstract excerpt

Previous studies have identified requirements for the binding of herpes simplex virus type 1 (HSV-1) to cells, including the presence of particular glycoproteins in the virion envelope (gC or gB) and the presence of particular glycosaminoglycan chains (principally heparan sulfate) on cell surface proteoglycans. We show here that neomycin, a known inhibitor of HSV infection, blocked early events in HSV infection...

Topics

Animals
Cell Line
Cricetinae
Heparin
Heparitin Sulfate
Herpesvirus 1, Human
Mutation
Neomycin
Protein Binding
Viral Envelope Proteins
Viral Plaque Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8030274
DOI: 10.1006/viro.1994.1469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8030274-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Neomycin inhibits glycoprotein C (gC)-dependent binding of herpes simplex virus type 1 to cells and also inhibits postbinding events in entry.PMID 8030274Read ↗

Resistance of herpes simplex virus type 2 to neomycin maps to the N-terminal portion of glycoprotein C.Semantic proximity Read ↗

Glycoprotein B plays a predominant role in mediating herpes simplex virus type 2 attachment and is required for entry and cell-to-cell spread.Semantic proximity Read ↗

Partial resistance to gD-mediated interference conferred by mutations affecting herpes simplex virus type 1 gC and gK.Semantic proximity Read ↗

Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread.Semantic proximity Read ↗

Modified entry and syncytium formation by herpes simplex virus type 1 mutants selected for resistance to heparin inhibition.Semantic proximity Read ↗

Herpes Simplex Virus Type‐1 (HSV‐1) Entry into Human Mesenchymal Stem Cells Is Heavily Dependent on Heparan SulfateSemantic proximity Read ↗

Involvement of glycoprotein C (gC) in adsorption of herpes simplex virus type 1 (HSV-1) to the cell.Semantic proximity Read ↗

Herpes simplex virus types 1 and 2 differ in their interaction with heparan sulfate.Semantic proximity Read ↗

Localization on the herpes simplex virus type 1 genome of a region encoding proteins involved in adsorption to the cellular receptor.Semantic proximity Read ↗

Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism.Semantic proximity Read ↗

Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity.Semantic proximity Read ↗

Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans.Semantic proximity Read ↗

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