Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread.

doi:10.1128/JVI.72.7.6119-6130.1998

Article

Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread.

Journal of virology - 1 Jul 1998

Laquerre S, Argnani R, Anderson D B, Zucchini S, Manservigi R, Glorioso J C

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) mutants defective for envelope glycoprotein C (gC) and gB are highly impaired in the ability to attach to cell surface heparan sulfate (HS) moieties of proteoglycans, the initial virus receptor. Here we report studies aimed at defining the HS binding element of...

Topics

Animals
Binding Sites
Chlorocebus aethiops
Heparan Sulfate Proteoglycans
Herpesvirus 1, Human
L Cells
Mice
Mutation
Vero Cells
Viral Envelope Proteins

Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread.

Abstract excerpt

Topics

Discuss the evidence