Article
A new assay based on thrombin generation inhibition to detect both protein C and protein S deficiencies in plasma.
Thrombosis and haemostasis - 1 Mar 1994
Duchemin J, Pittet J L, Tartary M, Béguin S, Gaussem P, Alhenc-Gelas M, Aiach M
Abstract excerpt
Activated protein C reduces thrombin generation by inactivating factors V and VIII in the presence of protein S. This prompted us to develop an assay which would allow specific exploration of this reaction. The total amount of thrombin formed in plasma after activation by tissue factor and phosph...
Topics
- Amino Acid Sequence
- Animals
- Blood Coagulation Tests
- Blood Preservation
- Chromogenic Compounds
- Factor V
- Factor VIII
- Female
- Genetic Variation
- Humans
- Lupus Coagulation Inhibitor
- Molecular Sequence Data
- Phospholipids
- Protein C
- Protein C Deficiency
- Protein S
- Protein S Deficiency
- Rabbits