Article
Cleaved antithrombin (ATc): a new marker for thrombin generation and activation of the coagulation system.
British journal of haematology - 1 Jan 1995
Lindo V S, Kakkar V V, Melissari E
Abstract excerpt
A modified form of antithrombin (AT) cleaved at the active site by thrombin (ATc) has been shown to be generated in vivo, corresponding to 1-4% of the circulating AT. An enzyme immunoassay has been developed for measuring ATc following plasma treatment with ammonium sulphate and heat denaturation...
Topics
- Acute Disease
- Adult
- Aged
- Amino Acid Sequence
- Ammonium Sulfate
- Antithrombins
- Biomarkers
- Blood Coagulation
- Blotting, Western
- Enzyme-Linked Immunosorbent Assay
- Female
- Hot Temperature
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Prothrombin