Article
Thrombin generation: phenotypic quantitation.
Journal of thrombosis and haemostasis : JTH - 1 Feb 2004
Brummel-Ziedins K E, Pouliot R L, Mann K G
Abstract excerpt
An individual's ability to generate thrombin following tissue factor stimulus was evaluated in 13 healthy male donors in a 6-month study. Thrombin generation in whole blood collected by phlebotomy, contact pathway suppressed by the presence of 100 micro g mL-1 corn trypsin inhibitor, was initiated by the addition of 5 pm tissue factor/10 nm phospholipid. Reactions were quenched at 20 min by the addition of an...
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