Article
A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity.
The Journal of biological chemistry - 8 Jul 1994
Mueckler M, Kruse M, Strube M, Riggs A C, Chiu K C, Permutt M A
Abstract excerpt
Glut2, the facilitative glucose transporter isoform expressed in pancreatic beta cells, is believed to play a role in glucose-stimulated insulin secretion. Two polymorphisms that result in amino acid substitutions have been reported in the human Glut2 gene (Tanizawa, Y., Riggs, A. C., Chiu, K. C....
Topics
- Animals
- Base Sequence
- Biological Transport
- Cloning, Molecular
- DNA
- Diabetes Mellitus, Type 2
- Glucose Transporter Type 2
- Humans
- Molecular Sequence Data
- Monosaccharide Transport Proteins
- Mutation
- Polymorphism, Genetic
- Xenopus