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Article

Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.

Diabetes - 1 Jun 2005

't Hart Leen M, Hansen Torben, Rietveld Ingrid, Dekker Jacqueline M, Nijpels Giel, Janssen George M C, Arp Pascal A, Uitterlinden André G, Jørgensen Torben, Borch-Johnsen Knut, Pols Huibert A P, Pedersen Oluf, van Duijn Cornelia M, Heine Robert J, Maassen J Antonie

Abstract excerpt

Previously, we have shown that a mutation in the mitochondrial DNA-encoded tRNA(Leu(UUR)) gene is associated with type 2 diabetes. One of the consequences of this mutation is a reduced aminoacylation of tRNA(Leu(UUR)). In this study, we have examined whether variants in the leucyl tRNA synthetase gene (LARS2), involved in aminoacylation of tRNA(Leu(UUR)), associate with type 2 diabetes. Direct sequencing of LARS2...

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Source

Identifiers

PMID: 15919814
DOI: 10.2337/diabetes.54.6.1892

Genes

LARS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.PMID 15919814Read ↗

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