Article
Mutations in SLC2A2 gene reveal hGLUT2 function in pancreatic β cell development.
The Journal of biological chemistry - 25 Oct 2013
Michau Aurélien, Guillemain Ghislaine, Grosfeld Alexandra, Vuillaumier-Barrot Sandrine, Grand Teddy, Keck Mathilde, L'Hoste Sébastien, Chateau Danielle, Serradas Patricia, Teulon Jacques, De Lonlay Pascale, Scharfmann Raphaël, Brot-Laroche Edith, Leturque Armelle, Le Gall Maude
Abstract excerpt
The structure-function relationships of sugar transporter-receptor hGLUT2 coded by SLC2A2 and their impact on insulin secretion and β cell differentiation were investigated through the detailed characterization of a panel of mutations along the protein. We studied naturally occurring SLC2A2 variants or mutants: two single-nucleotide polymorphisms and four proposed inactivating mutations associated to...
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