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Article

Serine-rich region of the IL-2 receptor beta-chain is required for activation of phosphatidylinositol 3-kinase.

Cellular immunology - 1 Jul 1994

Kanazawa T, Keeler M L, Varticovski L

Abstract excerpt

The intracellular portion of the IL-2 receptor (IL-2R) signal transducing beta-chain contains a distinct region, designated "serine-rich," which encompasses sequences required for IL-2-mediated cell growth. Although the receptor does not possess intrinsic protein-tyrosine kinase activity, IL-2 binding induces activation of intracellular protein-tyrosine kinases. Activation of many protein-tyrosine kinases leads...

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Identifiers

PMID: 8025955
DOI: 10.1006/cimm.1994.1183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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