Article
Serine-rich region of the IL-2 receptor beta-chain is required for activation of phosphatidylinositol 3-kinase.
Cellular immunology - 1 Jul 1994
Kanazawa T, Keeler M L, Varticovski L
Abstract excerpt
The intracellular portion of the IL-2 receptor (IL-2R) signal transducing beta-chain contains a distinct region, designated "serine-rich," which encompasses sequences required for IL-2-mediated cell growth. Although the receptor does not possess intrinsic protein-tyrosine kinase activity, IL-2 bi...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Enzyme Activation
- Gene Expression
- Humans
- Interleukin-2
- Molecular Sequence Data
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphoproteins
- Phosphotransferases (Alcohol Group Acceptor)
- Receptors, Interleukin-2
- Serine
- Signal Transduction
- Tyrosine