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Article

Phosphatidylinositol 3‐kinase is recruited to a specific site in the activated IL‐1 receptor I

30 Oct 1998

Abstract excerpt

Interleukin 1 (IL-1) delivers a stimulatory signal which increases the expression of a set of genes by modulating the transcription factor NF-kappaB. The IL-1 receptors are transmembrane glycoproteins which lack a catalytic domain. The C-terminal portion of the type I IL-1 receptor (IL-IRI) is essential for IL-1 signalling and for IL-1 dependent activation of NF-kappaB. This portion contains a putative...

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PMID: 9821957
DOI: 10.1016/s0014-5793(98)01270-8

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