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Article

p65/RelA binds and activates the <i>beclin 1</i> promoter

16 Aug 2009

Abstract excerpt

We unveiled novel p65/RelA consensus sites in the promoter of the beclin 1 gene and demonstrate that p65/RelA positively modulates canonical autophagy in various human cell lines both under basal conditions and upon induction by ceramide. Interestingly, we find that T cell receptor-dependent activation of Jurkat cells triggers an increase in the binding of p65/RelA to the beclin 1 promoter accompanied by enhanced...

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PMID: 19458474
DOI: 10.4161/auto.8822

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