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Article

Antibiotic treatment of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidis.

The Journal of infectious diseases - 1 Jul 1994

Entenza J M, Fluckiger U, Glauser M P, Moreillon P

Abstract excerpt

The natural history and treatment of experimental endocarditis due to heterogeneous and homogeneous methicillin-resistant Staphylococcus epidermidis was investigated. Amoxicillin/clavulanate or vancomycin were administered for 3 days via a computerized pump to mimic human drug kinetics in animals. After challenge with the minimum inoculum producing 90% of infections (ID90), bacteria in the vegetations grew...

Topics

Amoxicillin
Animals
Clavulanic Acid
Clavulanic Acids
Drug Therapy, Combination
Endocarditis
Female
Humans
Kinetics
Methicillin Resistance
Phenotype
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Wistar

Staphylococcal Infections

Staphylococcus epidermidis

Vancomycin

Source

Identifiers

PMID: 8014483
DOI: 10.1093/infdis/170.1.100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8014483-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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