Article
Activity of isepamicin and selection of permeability mutants to beta-lactams during aminoglycoside therapy of experimental endocarditis due to Klebsiella pneumoniae CF104 producing an aminoglycoside acetyltransferase 6' modifying enzyme and a TEM-3 beta-lactamase.
The Journal of infectious diseases - 1 Jun 1994
Mainardi J L, Zhou X Y, Goldstein F, Mohler J, Farinotti R, Gutmann L, Carbon C
Abstract excerpt
The pharmacokinetics and efficacy of isepamicin were compared with those of amikacin and gentamicin in a rabbit model of endocarditis due to Klebsiella pneumoniae CF104 producing beta-lactamase TEM-3 and aminoglycoside acetyltransferase AAC(6')-IV. Only isepamicin and gentamicin, alone or combined with ceftriaxone, were effective as determined by titration of viable bacteria in vegetations. Variants highly...
Topics
- Acetyltransferases
- Amikacin
- Animals
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Cell Membrane Permeability
- Disease Models, Animal
- Drug Therapy, Combination
- Endocarditis