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Article

Staphylococcus aureus menD and hemB mutants are as infective as the parent strains, but the menadione biosynthetic mutant persists within the kidney.

The Journal of infectious diseases - 15 May 2003

Bates Donna M, von Eiff Christof, McNamara Peter J, Peters Georg, Yeaman Michael R, Bayer Arnold S, Proctor Richard A

Abstract excerpt

Small colony variants (SCVs) of Staphylococcus aureus were generated via mutations in menD or hemB, yielding menadione and hemin auxotrophs, respectively, and studied in the rabbit endocarditis model. No differences in the 95% infectious dose occurred between strains with regard to seeding heart valves ( approximately 10(6) cfu) or other target organs. No differences were observed between the response of the hemB...

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PMID: 12721946
DOI: 10.1086/374642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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