Effective treatment of cephalosporin-rifampin combinations against cryptic methicillin-resistant beta-lactamase-producing coagulase-negative staphylococcal experimental endocarditis.

Abstract excerpt

The efficacy of cefazolin or cefpirome alone or combined with rifampin was compared with that of vancomycin alone or combined with rifampin in an experimental model of methicillin-resistant, beta-lactamase-producing, coagulase-negative staphylococcal endocarditis. Phenotypically, the mecA gene-positive strain used in vivo did not exhibit methicillin resistance by the agar dilution or disk susceptibility method...

Topics

• Animals
• Antibiotics, Antitubercular
• Cephalosporins
• Coagulase
• Drug Synergism
• Drug Therapy, Combination
• Endocarditis, Bacterial
• Methicillin Resistance
• Microbial Sensitivity Tests
• Phenotype