Article
Importance of genotypic and phenotypic tolerance in the treatment of experimental endocarditis due to Streptococcus gordonii.
The Journal of infectious diseases - 1 Jan 1997
Entenza J M, Caldelari I, Glauser M P, Francioli P, Moreillon P
Abstract excerpt
Genotypic and phenotypic tolerance was studied in penicillin treatment of experimental endocarditis due to nontolerant and tolerant Streptococcus gordonii and to their backcross transformants. The organisms were matched for in vitro and in vivo growth rates. Rats with aortic endocarditis were tre...
Topics
- Animals
- Anti-Bacterial Agents
- Aortic Valve
- Bacteremia
- Drug Resistance, Microbial
- Drug Tolerance
- Endocarditis, Bacterial
- Female
- Genotype
- Microbial Sensitivity Tests
- Mutation
- Penicillins
- Phenotype
- Rats
- Rats, Wistar
- Serum Bactericidal Test
- Spleen
- Streptococcal Infections