Article
Efficacy of prophylaxis with beta-lactams and beta-lactam-beta-lactamase inhibitor combinations against wound infection by methicillin-resistant and borderline-susceptible Staphylococcus aureus in a guinea pig model.
Antimicrobial agents and chemotherapy - 1 Apr 1993
Kernodle D S, Kaiser A B
Abstract excerpt
Although some beta-lactams and beta-lactam-beta-lactamase inhibitor combinations exhibit activity against methicillin-resistant Staphylococcus aureus, there remains the concern that therapeutic failures may result from the selection of resistant subpopulations. The prophylactic use of these antib...
Topics
- Ampicillin
- Animals
- Anti-Bacterial Agents
- Cefazolin
- Female
- Guinea Pigs
- Male
- Methicillin Resistance
- Phenotype
- Regression Analysis
- Serum Bactericidal Test
- Staphylococcal Infections
- Staphylococcus aureus
- Sulbactam
- Wound Infection
- beta-Lactamase Inhibitors