Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficacy of iclaprim against wild-type and thymidine kinase-deficient methicillin-resistant Staphylococcus aureus isolates in an in vitro fibrin clot model.

Antimicrobial agents and chemotherapy - 1 Sept 2009

Entenza José M, Haldimann Andreas, Giddey Marlyse, Lociuro Sergio, Hawser Stephen, Moreillon Philippe

Abstract excerpt

Iclaprim is a novel diaminopyrimidine antibiotic that is active against methicillin-resistant Staphylococcus aureus (MRSA). However, it is known that the activity of diaminopyrimidines against S. aureus is antagonized by thymidine through uptake and conversion to thymidylate by thymidine kinase. Unlike with humans, for whom thymidine levels are low, thymidine levels in rodents are high, thus precluding the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Methicillin-Resistant Staphylococcus aureus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microbial Sensitivity Tests

Share to Pyrimidines

Share to Thymidine Kinase

Share to Trimethoprim, Sulfamethoxazole Drug Combination

Share to Vancomycin

Source

Open in PubMed Open full text

Identifiers

PMID: 19564362
DOI: 10.1128/AAC.00325-09
PMCID: PMC2737851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficacy of iclaprim against wild-type and thymidine kinase-deficient methicillin-resistant Staphylococcus aureus isolates in an in vitro fibrin clot model.PMID 19564362Read ↗

Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activitySemantic proximity Read ↗

Efficacy of human simulated exposures of ceftaroline administered at 600 milligrams every 12 hours against phenotypically diverse Staphylococcus aureus isolates.Semantic proximity Read ↗

Phage activity against Staphylococcus aureus is impaired in plasma and synovial fluidSemantic proximity Read ↗

In vivo comparison of CXA-101 (FR264205) with and without tazobactam versus piperacillin-tazobactam using human simulated exposures against phenotypically diverse gram-negative organisms.Semantic proximity Read ↗

Antibiotic treatment of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidis.Semantic proximity Read ↗

Anti-thrombotic treatment enhances antibiotic efficiency in a humanized model of meningococcemiaSemantic proximity Read ↗

Staphylococcus aureus menD and hemB mutants are as infective as the parent strains, but the menadione biosynthetic mutant persists within the kidney.Semantic proximity Read ↗

In Vivo Pharmacodynamic Activities of Two Glycylcyclines (GAR-936 and WAY 152,288) against Various Gram-Positive and Gram-Negative BacteriaSemantic proximity Read ↗

In Vivo Pharmacodynamic Activity of the Glycopeptide DalbavancinSemantic proximity Read ↗

Ceftaroline fosamil in the treatment of experimental meningitis caused by methicillin-resistant Staphylococcus aureusSemantic proximity Read ↗

Efficacy of daptomycin in the treatment of experimental endocarditis due to susceptible and multidrug-resistant enterococciSemantic proximity Read ↗

Efficacy of human simulated exposures of ceftaroline against phenotypically diverse Enterobacteriaceae isolates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.