p53 genetic abnormalities and myc activation in human lung carcinoma.

doi:10.1002/ijc.2910580106

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Article

p53 genetic abnormalities and myc activation in human lung carcinoma.

International journal of cancer - 1 Jul 1994

Gazzeri S, Brambilla E, Caron de Fromentel C, Gouyer V, Moro D, Perron P, Berger F, Brambilla C

Abstract excerpt

p53 mutations and myc gene amplification and expression were studied in 119 lung carcinomas of all histological types. A mutant p53 immunophenotype was previously found in 47% of these tumors by immunohistochemical analysis. Seven cases exhibited p53 genomic rearrangements on Southern blots. Elev...

Topics

Base Sequence
Gene Amplification
Gene Expression
Gene Expression Regulation, Neoplastic
Genes, myc
Genes, p53
Humans
Immunophenotyping
Lung Neoplasms
Molecular Sequence Data
Mutation
Prognosis
RNA, Messenger
Transcription, Genetic

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Open in PubMed

Identifiers

PMID: 8014012
DOI: 10.1002/ijc.2910580106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8014012-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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