Article
Analysis of the activation of the myc family oncogene and of its stability over time in xenografted human lung carcinomas.
Cancer research - 1 Mar 1990
Gazzeri S, Brambilla E, Chauvin C, Jacrot M, Benabid A L, Brambilla C
Abstract excerpt
In order to validate the use of the nude mouse as a model for studying lung cancers, 21 different lung cancers were xenografted onto nude mice and the tumoral DNA and RNA were analyzed for abnormality in the myc family genes (c-myc, L-myc, and N-myc). Six of 14 small cell lung cancers (SCLC) showed a 4-35-fold amplification for L-myc, 5 of 7 non-SCLC a 3-5-fold amplification for c-myc, and 1 of 14 SCLC an 80-fold...
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