Analysis of the activation of the myc family oncogene and of its stability over time in xenografted human lung carcinomas.

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Article

Analysis of the activation of the myc family oncogene and of its stability over time in xenografted human lung carcinomas.

Cancer research - 1 Mar 1990

Gazzeri S, Brambilla E, Chauvin C, Jacrot M, Benabid A L, Brambilla C

Abstract excerpt

In order to validate the use of the nude mouse as a model for studying lung cancers, 21 different lung cancers were xenografted onto nude mice and the tumoral DNA and RNA were analyzed for abnormality in the myc family genes (c-myc, L-myc, and N-myc). Six of 14 small cell lung cancers (SCLC) show...

Topics

Animals
Carcinoma, Non-Small-Cell Lung
Carcinoma, Small Cell
Gene Amplification
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms
Mice
Mice, Nude
Neoplasm Transplantation
Oncogenes
Phenotype
Time Factors
Transcriptional Activation

Source

Open in PubMed

Identifiers

PMID: 2154327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2154327-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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