Article
Genetic and structural evidence for antigen selection of anti-DNA antibodies.
Annual review of immunology - 1 Jan 1994
Radic M Z, Weigert M
Abstract excerpt
The primary structure of anti-DNA antibodies is highly diverse, a result of different germline variable (V) gene use, different combinations of immunoglobulin gene segments, peculiar heavy chain complementarity determining region 3 (H-CDR3) segments, and somatic mutations. Nevertheless, tertiary structure predictions reveal common features that yield information about likely contact sites in the anti-DNA...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Antinuclear
- Base Sequence
- Binding Sites, Antibody
- DNA
- Humans
- Molecular Sequence Data
- Mutation
- Sequence Homology, Amino Acid