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Article

Disposition of clozapine and desmethylclozapine in schizophrenic patients.

Journal of clinical pharmacology - 1 Apr 1994

Lin S K, Chang W H, Chung M C, Lam Y W, Jann M W

Abstract excerpt

The disposition of the atypical clozapine and its desmethyl metabolite were evaluated in fourteen male chronic patients. A single 100 mg dose of clozapine was administered and blood sampling performed over the following 72 hours. The mean (SD) oral clearance and half-life of clozapine were 55.4 (29.7) L/hr and 13.7 (9.9) hours, respectively. The mean (SD) AUC for clozapine and desmethylclozapine was 2389.9 (1406)...

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Source

Identifiers

PMID: 8006199
DOI: 10.1002/j.1552-4604.1994.tb02000.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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