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Article

Disposition of clozapine and desmethylclozapine in schizophrenic patients.

Journal of clinical pharmacology - 1 Apr 1994

Lin S K, Chang W H, Chung M C, Lam Y W, Jann M W

Abstract excerpt

The disposition of the atypical clozapine and its desmethyl metabolite were evaluated in fourteen male chronic patients. A single 100 mg dose of clozapine was administered and blood sampling performed over the following 72 hours. The mean (SD) oral clearance and half-life of clozapine were 55.4 (...

Topics

Adult
Chronic Disease
Clozapine
Dextromethorphan
Half-Life
Homovanillic Acid
Humans
Male
Metabolic Clearance Rate
Middle Aged
Phenotype
Schizophrenia

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Identifiers

PMID: 8006199
DOI: 10.1002/j.1552-4604.1994.tb02000.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8006199-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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