Article
Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes.
Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2008
Zhang Wei V, D'Esposito Fabrizio, Edwards Robert J, Ramzan Iqbal, Murray Michael
Abstract excerpt
The atypical antipsychotic drug clozapine (CLZ) is effective in a substantial number of patients who exhibit treatment-resistance to conventional agents. CYP1A2 is generally considered to be the major enzyme involved in the biotransformation of CLZ to its N-demethylated (norCLZ) and N-oxygenated (CLZ N-oxide) metabolites in liver, but several studies have also implicated CYP3A4. The present study assessed the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.