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Article

Metabolism and bioactivation of clozapine by human liver in vitro.

The Journal of pharmacology and experimental therapeutics - 1 Mar 1995

Pirmohamed M, Williams D, Madden S, Templeton E, Park B K

Abstract excerpt

The metabolism of clozapine by human liver has been investigated in vitro. Irreversible protein-binding and conjunction with model nucleophiles have been used as markers for bioactivation of clozapine, while stable metabolite formation has been assessed using radiometric HPLC. In all nine liver microsomal preparations investigated, clozapine was extensively metabolized to the stable products desmethylclozapine...

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Source

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PMID: 7891353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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