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Article

Metabolism and bioactivation of clozapine by human liver in vitro.

The Journal of pharmacology and experimental therapeutics - 1 Mar 1995

Pirmohamed M, Williams D, Madden S, Templeton E, Park B K

Abstract excerpt

The metabolism of clozapine by human liver has been investigated in vitro. Irreversible protein-binding and conjunction with model nucleophiles have been used as markers for bioactivation of clozapine, while stable metabolite formation has been assessed using radiometric HPLC. In all nine liver m...

Topics

Adult
Ascorbic Acid
Biotransformation
Child
Clozapine
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Female
Genotype
Humans
In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsomes, Liver

Mixed Function Oxygenases

Sulfhydryl Compounds

Source

Identifiers

PMID: 7891353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7891353-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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